Research Profile of the Department of Clinical Pharmacology
The Department of Clinical Pharmacology conducts its research activities across several key areas:
- Pharmacoepidemiology and Pharmacoeconomics of socially significant diseases.
- Clinical trials of innovative domestically developed pharmaceutical drugs.
-
Rational pharmacotherapy for:
- Elderly and senile patients with multimorbidity;
- Women during pregnancy and lactation;
- Pediatric patients.
- Rational use of antibacterial drugs.
Research Facilities
Department staff conduct research utilizing the clinical facilities where the department operates, including:
- N.E. Savchenko 4th City Clinical Hospital, Minsk.
- 3rd City Children's Outpatient Clinic, Minsk.
- "City Children's Infectious Clinical Hospital" Healthcare Institution.
- Other treatment, preventive, and research institutions in Minsk.
International Research Collaboration
The department maintains active collaborative ties with leading foreign scientific organizations, such as:
- Federal State Budgetary Institution "Expertise and Quality Control Center for Medical Care" of the Ministry of Health of the Russian Federation.
- Department of Clinical Pharmacology and Therapy, Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation.
- Professional Medical Association of Clinical Pharmacologists of St. Petersburg and the Interregional Public Organization "Association of Clinical Pharmacologists" of the Russian Federation.
- Department of Clinical Pharmacology, Institute of Fundamental Medicine, Kazan Federal University.
- N.N. Burdenko Voronezh State Medical University of the Ministry of Health of the Russian Federation.
- Department of Pharmacology and Clinical Pharmacology with Postgraduate Studies, Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation.
Current and Planned Research
For 2025, the department has approved a research project titled "Improving the Pharmacotherapy System for Specific Socially Significant Diseases."
Planned activities for 2026-2027 include:
- Analysis of regulatory legal acts of the Republic of Belarus governing drug use, the operation of the clinical pharmacology service, and the development of local healthcare institution documents for drug application tailored to specific clinical practices.
- Analysis of the etiological structure of infections and microbial susceptibility to antimicrobial agents in adult and pediatric inpatients, employing modern technical and laboratory capabilities (including therapeutic drug monitoring for antibacterial agents, etc.).
- Investigation of multimorbidity issues within inpatient healthcare settings.
Dissertation Defenses
Candidate of Medical Sciences (Ph.D.) Defenses:
- 1999: Korolevich M.P. – "Antimicrobial Activity of Antibiotics and Antiseptics against Pathogens of Postoperative Wound Infection" (Supervisor: Prof. Adarchenko A.S., Dr. Med. Sci.).
- 2000: Tahanovich N.D. – "Pharmacological Properties of Ditolonium – A New Peripheral-Action Muscle Relaxant" (Supervisor: Prof. Zakharevsky A.S., Dr. Med. Sci.).
- 2006: Novikova I.V. – "Experimental and Clinical Justification for the Use of Cyclocytidinemonophosphate in the Treatment of Ophthalmic Herpes" (Supervisor: Prof. Kevra M.K., Dr. Med. Sci.).
- 2007: Nekhaeva I.A. – "Pharmacokinetics of Methadone Transplacental Transfer" (Supervisor: Prof. Kevra M.K., Dr. Med. Sci.).
- 2008: Romanova I.S. – "Drug Therapy and Clinical Outcomes in Patients with Myocardial Infarction in Routine Clinical Practice" (Supervisor: Prof. Khapaliuk A.V., Dr. Med. Sci.).
- 2008: Kozhanova I.S. – "Pharmacoepidemiological and Pharmacoeconomic Assessment of Treatment Effectiveness for Chronic Obstructive Pulmonary Disease" (Supervisor: Prof. Khapaliuk A.V., Dr. Med. Sci.).
- 2017: Sorokina V.N. – "Multifactorial Risk Assessment for Arterial Hypertension Development in Men" (Supervisor: Prof. Khapaliuk A.V., Dr. Med. Sci.).
- 2018: Chak T.A. – "Clinical, Metabolic, Genetic, and Cellular-Molecular Characteristics of Distal Polyneuropathy in Type 2 Diabetes Mellitus" (Supervisor: Prof. Khapaliuk A.V., Dr. Med. Sci.).
Doctor of Medical Sciences (Dr. Med. Sci.) Defenses:
9. 2004: Kevra M.K. – "Systemic Action of Tumor Necrosis Factor Alpha and Clinical Efficacy of Its Modifiers in Rheumatoid Arthritis and Sepsis."
10. 2023: Kozhanova I.N. – "Systemic Foundations for Health Technology Assessment."
Dissertations in Preparation
- Dr. Med. Sci.: Gavrilenko L.N. – "Organizational Technologies for Optimizing Rational Drug Use" (Specialty: Public Health and Healthcare). Scientific Consultant: Prof. Sachek M.M., Dr. Med. Sci. (Research period: 11/01/2022 – 10/31/2027, Institute for Advanced Training and Retraining, Belarusian State Medical University).
- Dr. Med. Sci.: Ruban Anna Petrovna – "Acute Allergic Reactions in Children: Optimization of Diagnosis and Medical Prevention" (Specialty: Pediatrics). Scientific Consultant: Prof. Vasilevsky I.V., Dr. Med. Sci. (Research period: 11/01/2023 – 10/31/2028, Belarusian State Medical University). Topic and consultant approved by the BSMU Academic Council on November 21, 2023.
- Cand. Med. Sci. (Ph.D.): Kendenkov O.I. – "Organization of Antibacterial Therapy Control in Hospital Settings" (Specialty: Pharmacology, Clinical Pharmacology). Scientific Supervisor: L.N. Gavrilenko, Associate Professor of the Department of Clinical Pharmacology, BSMU (Research period: November 2023 – November 2028).
Expert and Editorial Activities
Department staff are consistently engaged in expert work, providing reviews for doctoral and candidate dissertations, scientific publications, research and development project proposals, as well as textbooks and teaching materials. They serve on editorial boards of periodic scientific journals and participate in the work of expert councils, including the Higher Attestation Commission (VAK) and dissertation defense committees.
Scientific and Expert Roles of Department Staff
- Head of Department, Associate Professor Romanova I.S. – Chief External Specialist in Clinical Pharmacology for the Ministry of Health of the Republic of Belarus. Expert of the Republican Formulary Committee of the Ministry of Health. Member of the Belarusian Regional Chapter of ISPOR (International Society for Pharmacoeconomics and Outcomes Research). Board Member of the Public Medical Association "Clinical Pharmacology and Therapy." Member of the Editorial Board of the international scientific-practical journal "RECEPT." Member and expert of the Ministry of Health Commission on Medicinal Products; member of the Ministry of Health Commission for Registration and Sale of Dietary Supplements.
- Professor Vasilevsky I.V. – Deputy Chairman of the Dissertation Council D 03.18.01 at BSMU (specialties: Obstetrics, Pediatrics); Member of Dissertation Council D 03.18.04 at BSMU (specialties: Infectious Diseases, Allergology, Immunology). Editorial Board Member for several international medical journals. Expert of the Ministry of Health Commission on Medicinal Products. Scientific Consultant for the ongoing doctoral dissertation on "Acute Allergic Reactions in Children."
- Professor Kevra M.K. – Head of the Minsk City Advisory Center for Drug Pathology, based at the N.E. Savchenko 4th City Clinical Hospital. Editorial Board Member of the journals "Drugs and Rational Pharmacotherapy" (Russian Federation) and "Healthcare" (Republic of Belarus).
- Professor Kozhanova I.N. – Chief External Specialist in Clinical Pharmacology for the Minsk Regional Executive Committee Health Department. Expert of the Republican Formulary Committee. Member of ISPOR. Board Member of the Public Medical Association "Clinical Pharmacology and Therapy." Editorial Board Member of the journal "RECEPT." Member of the Scientific and Technical Council for the "Internal Medicine" subprogram. Member of Dissertation Council D 03.18.09 at BSMU. Member of the Expert Commission on Therapy of the Ministry of Health's Scientific Medical Council.
- Professor Gavrilenko L.N. – Chairman of the Board of the Public Medical Association "Clinical Pharmacology and Therapy." Editor-in-Chief of the international journal "RECEPT." Editorial Board Member for several national and international journals. Holds multiple key positions: Member of the Treatment Control Council and the Scientific-Methodological Council of BSMU; Deputy Chair of the Methodological Commission for Therapeutic Disciplines at BSMU; Member of expert councils on immunization and therapy; Head of the Secretariat and Member of the Republican Formulary Committee; Chair of the Ministry of Health Commission for Registration and Sale of Dietary Supplements; Member of the BSMU Bioethics Committee. Member of ISPOR and ISoP (International Society of Pharmacovigilance).
Conference Participation and Organization
The Department of Clinical Pharmacology actively participates in international, national, and regional scientific events (congresses, conferences, symposia, expert panels) on current issues in clinical pharmacology and rational pharmacotherapy. The department also regularly organizes republic-level scientific forums with international participation, including congresses, conferences, symposia, seminars, and schools for clinical pharmacologists.