The scientific achievements of the Department of Pathological Physiology in the field of experimental medicine are important for understanding the etiology and pathogenesis of conditions accompanied by endotoxinemia and an increase in body temperature, the mechanisms of thermal stability. They are the scientific justification for the targeted pharmacological effect on the detoxification and endotoxin-neutralizing function of the liver in order to maintain homeostasis in hyperthermia and bacterial endotoxinemia, correction of heat transfer processes and increasing the body's thermal resistance.
- The regulatory and pathogenetic role of liver arginase and its detoxification function in maintaining the thyroid status and the formation of thermoregulatory reactions of the body during overheating and bacterial endotoxinemia has been established;
- Previously unknown features and patterns of thermoregulation in conditions of functional liver failure, its detoxification and endotoxin-neutralizing functions have been revealed, which makes it possible to consider detoxification processes, liver arginase activity, levels of α1-antitrypsin, valine, urea and triiodothyronine in the blood as important factors in maintaining temperature homeostasis;
- The relationship and significance of the interaction between the pituitary-thyroid gland system, thermoregulation, the activity of liver arginase and α1-antitrypsin of blood plasma during overheating and endotoxin fever was revealed;
- It was found that a decrease in the activity of α1-antitrypsin in the blood is important in the mechanisms of maintaining temperature homeostasis, the formation of the thyroid status and thermoregulatory reactions of the body under the action of a high external temperature An increase in the activity of α1-antitrypsin is an important pathogenetic factor of endotoxin fever;
- It was found that a1-antitrypsin of blood plasma is involved in changes in the detoxification function of the liver and body temperature induced by triiodothyronine introduced into the body and determines the nature of changes in the level of triiodothyronine in the blood, detoxification function of the liver and heat exchange on the action of high external temperature and bacterial endotoxin;
- It was revealed that depression of the processes of formation of nitrogen monoxide is one of the factors leading to a decrease in the activity of the pituitary-thyroid gland system, detoxification function of the liver and the development of endotoxemia, and the peculiarities of changes in body temperature and the nature of the formation of thermoregulatory reactions of the body in rats and rabbits to the effect of bacterial endotoxin in conditions of inhibition of the synthesis of nitrogen monoxide are associated with a violation of the thyroid status of the body, the state of the liver, its detoxification function;
- It has been proved that nitrogen monoxide is one of the factors regulating the function of hepatocytes and their resistance to the damaging action of carbon tetrachloride, an important factor in realizing the effect of hepatotropic poison on the processes of energy supply of the body and thermoregulation;
- It was found that depression of Kupffer cells is the most important factor in the formation of a hyperthyroid state of the body, an increase in the detoxification function of the liver and body temperature;
- It was found that the level of triiodothyronine in the blood plasma determines the severity of detoxification processes in the liver in chronic ethanol intoxication;
- It was revealed that the activity of Kupffer cells is important in the mechanisms of the hepatotoxic effect of ethanol in chronic alcoholism.
- It was found that the formation of thyroid hypofunction in bacterial endotoxinemia plays a compensatory role and weakens the development of disorders of blood lipoprotein metabolism characteristic of endotoxinemia.
- It was found that an increase in the activity of the central α-adrenoreactive systems plays an important role in the mechanisms of realization of the antipyretic action of acupuncture upon stimulation of analogs of points LU-11 and LI-1, as well as L1-11 and TH-5 under conditions of fever caused by bacterial endotoxin and that monoxide nitrogen is involved in the mechanisms of the central action of α-adrenergic agonists on body temperature and heat transfer processes in bacterial endotoxinemia;
- The pathogenetic links of thermoregulation disorders mediated by the activity of liver arginase and the level of valine in the blood during overheating and endotoxin fever have been determined;
- The compensatory and adaptive role of a decrease in the activity of liver arginase for the formation of processes of thermal stability during overheating has been proved, and its increase as an important pathogenetic factor of endotoxin fever;
- The antipyretic effect of the amino acid L-valine in conditions of endotoxin fever and its participation in the mechanisms of endogenous antipyresis and an increase in heat resistance and survival of animals during overheating have been established;
- The importance of liver arginase activity for increasing its detoxification function and body temperature in rats in experimental hyperthyroidism has been proved;
- It was found that an increase in the level of urea in the blood is one of the factors of endogenous antipyresis.
- The dependence of the liver arginase activity and body temperature in rats on the urea content in the blood under conditions of overheating and endotoxin fever was revealed, and the possibility of using L-valine to reduce the level of urea in the blood in order to increase thermal stability during overheating and as an antipyretic agent in fever was experimentally substantiated;
- The significance of bacterial endotoxinemia in the occurrence of thyroid dysfunction and the pathogenesis of dysregulatory pathology has been established.
