Research Work of Oncology

Subjects of the Department:

Diagnosis and treatment of tumors of breast, abdominal and pelvic organs

The main directions of the scientific activity of the Department are:

1. Epidemiology, diagnosis, treatment and prevention of pre-tumor and tumor lesions of the hepatopancreatodenoduedal zone.
2. Epidemiology, diagnosis, treatment and prognosis of stomach and gastroesophageal cancer.
3. Development and implementation of the additional criteria for the risk of non-small cell lung cancer, the course and prognosis of the disease based on the molecular genetic characteristics of patients.
4. Development of personalized treatments for locally-advanced uterine carcinoma and disseminate colorectal cancer.
5. Development and implementation of the method of metronome supporting chemotherapy in patients with disseminate colorectal cancer.
6. Immunotherapy based on autologous dendritic cells in patients with epithelial tumors (pancreatic cancer, colorectal cancer, tumors of the urogenital zone, breast cancer).
7. Development of methods to identify circulating tumor cells and cancer stem cells to assess the effectiveness of complex treatment of tumors of different localization

The research was carried out within the framework of scientific and technical projects in cooperation with the Institute of Biophysics and Cell Engineering of NAS RB, the Institute of Genetics of NAS RB, Republican Scientific and Practical Center for Epidemiology and Microbiology, Republican Scientific and Practical Center for Oncology and Medical Radiology named after N.N. Aleksandrov:

• Personalization of treatment of patients with locally-advanced uterine carcinoma and disseminate colorectal cancer. Scientific Leader:  Prokhorov А.V. The period of execution: 01.01.2016–31.12.2020.
• To develop and implement a method of metronome supporting chemotherapy in patients with disseminate colorectal cancer. Scientific Leader:  of Medical Sciences, Professor Prokhorov A.V. The period of execution period:  01.07.2016–30.06.2019.
• Clinical use and evaluation of the effectiveness of autologous dendritic cells in patients with pancreatic cancer. The period of execution: 01.07.2016–30.06.2019.
• Analysis of clinical indicators in patients with adenocarcinoma and squamous cell lung cancer. Scientific Leader and Responsible Executor: Candidate of Medical Sciences, Associate-Professor Michail N. Shapetjko. The period of execution: 01.07.2015–31.12.2016.
• Clinical application and evaluation of the effectiveness of cellular immunotherapy based on autologous dendritic cells in the complex treatment of patients with recurrent bladder cancer. The period of execution: 01.01.2019–31.12.2020. Scientific Leader:  of Medical Sciences, Professor Prokhorov A.V.
• Clinical use of methods to determine the immunophenotypic profile of circulating tumor cells and circulating cancer stem cells in the diagnosis and treatment of malignancies of major localizations”. The Period of execution: 01.01.2020–31.12.2020. Scientific Leader:  of Medical Sciences, Professor Prokhorov A.V

At the Department the following dissertation research is carried out:

1. “Diagnosis and treatment of non-small cell lung cancer based on the molecular genetic characteristics of the patient”.  Applicant, Candidate of Medical Sciences, Associate-Professor Michail N. Shapetjko.

2.  “Molecular-biological characteristics of gastrointestentential stromal tumors of various localizations and the choice of treatment method for localized and common forms”.  Applicant Larisa A. Kursakova.

• “Radiofrequency ablation in the treatment of colorectal cancer metastases in the liver”.  Applicant Victoria Y. Alechnovich.
• “Metronom supporting chemotherapy of patients with disseminated colorectal cancer”. Applicant Olga V. Streltsova.
• “Complex treatment of aggressive stage I uterine cancer”. Applicant Maria V. Choroshun.
• “Multimodal treatment for non-resectable cervical cancer”. Applicant Irina M. Pranovich.
• “Dendritic cell immunotherapy in the treatment of metastatic renal cell cancer”. Applicant Alexander V. Bresovsky.
• “Diagnosis of pancreatic cancer based on genetic and laboratory-instrumental methods of research”. Applicant Irina V. Smolyakova.
• “Perioperative chemotherapy in the treatment of locally-advanced gastric cancer”. Applicant Svetlana D. Philippova.

Instructions for Use

Annually the Department organizes BSMU Days (Section “Oncology”) and the student scientific conference “Actual Problems of Modern Medicine and Pharmacy (Section “Oncology”).