Academic and scientific researches of the department are determined by the interdisciplinary nature of bioorganic chemistry and laid down by prominent scientists and organizers of education. Research in the field of organic chemistry and the chemistry of natural compounds have been started under the leadership of Academicians A.M. Pryliazhaeu (oxidation of unsaturated compounds) and M.S. Kazlou (chemistry of natural compounds, synthesis of monomers). Investigations in the field of physical chemistry and kinetics of biochemical processes are associated with the names of the heads of the department professors E.N. Novikova, A.I. Balakleevsky and I.V. Romanovsky. Those pioneer works created the ground for the development of the researches in the field of biochemistry of normal and pathological processes as well as the Chemistry of small molecules with biological activity.
Research areas
1. Bioorganic chemistry and chemistry of natural compounds
1.1. Synthesis and chemistry, as well as SAR of biologically active compounds in the search for new drugs
1.2. Synthesis and isolation of steroids and other isoprenoids from natural sources
1.3. Synthesis and study of analogs of natural pteridine derivative.
2. Biochemistry of normal and pathological conditions
2.1. Thiol-disulfide metabolism in experimental thyroid pathology in context of aging
2.2. Phenotypic and genotypic heterogeneity of tumor tissues
2.3. Redox status of the organism under stress and endocrine pathology
2.4. In silico study of biologically active substances and their role in the biochemical processes
2.5. Biochemical processes underlying thyroid hormone metabolism
2.6. Bioorganic approaches to the development of laboratory diagnostic methods
3. Organic chemistry
3.1. Synthesis and structural studies of organic substances (carbonyl compounds, derivatives of piperidine, pteridine, etc.) in the search of the biologically active substances
3.2. Mechanisms and stereochemistry of chemical reactions (addition to carbonyl group, oxidation, etc.).
3.3. Chemistry of a catalytic fossil fuel production
4. Physical chemistry of chemical and biochemical processes, improvement of methods for the isolation, purification and identification of substances and processes
4.1. Adaptation of PCR methods for biomedical and clinical research
4.2. Methods for studying biological processes (HPLC, electrophoresis, spectrophotometry, molecular docking, etc.)
5. Pharmaceutical and toxicological chemistry
5.1. Molecular Docking in the rational drug design
5.2. Chemical and toxicological analysis of drugs and other xenobiotics
6. Philosophy and methodology of science, didactics of chemistry
6.1. Visualization and modeling, aesthetics and psychology of chemistry meaning (chemical objects and processes)
6.2. Methodology and didactics of organic and bioorganic chemistry
6.3. Innovative technologies of teaching chemistry in secondary and higher education
As part of scientific research, the department carries out postgraduate training in the specialty “Biochemistry” (Biological and medical sciences), students of all faculties are actively involved in SR activity.
Results have been presented at international scientific conferences and symposia (Latvia, Lithuania, Greece, Ukraine, Spain, Poland, Russia, Czech Republic, France, Croatia, Estonia, etc.). Professor J. Ramanouski supervises the cooperation of BSMU with the International Council for Hospital Hygiene of Germany, associate professor T. Lakhvich is a member of the editorial board of the international scientific Journal of Baltic Science Education, took part in the meetings of the FEBS Education Committee as Education ambassador.